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A Newly Classified Vertebrate Calpain Protease, Directly Ancestral to CAPN1 and 2, Episodically Evolved a Restricted Physiological Function in Placental Mammals

Macqueen, Daniel J.; Delbridge, Margaret; Manthri, Sujatha; Johnston, Ian A.

Description

The most studied members of the calpain protease superfamily are CAPN1 and 2, which are conserved across vertebrates. Another similar family member called μ/m-CAPN has been identified in birds alone. Here, we establish that μ/m-CAPN shares one-to-one or

dc.contributor.authorMacqueen, Daniel J.
dc.contributor.authorDelbridge, Margaret
dc.contributor.authorManthri, Sujatha
dc.contributor.authorJohnston, Ian A.
dc.date.accessioned2015-12-10T23:02:57Z
dc.identifier.issn0737-4038
dc.identifier.urihttp://hdl.handle.net/1885/61966
dc.description.abstractThe most studied members of the calpain protease superfamily are CAPN1 and 2, which are conserved across vertebrates. Another similar family member called μ/m-CAPN has been identified in birds alone. Here, we establish that μ/m-CAPN shares one-to-one or
dc.publisherSociety for Molecular Biology Evolution
dc.sourceMolecular Biology and Evolution
dc.subjectKeywords: calpain; calpain 1; calpain 11; calpain 2; calpastatin; unclassified drug; amino acid sequence; article; gene control; gene expression; gene mutation; genetic code; genetic transcription; marsupial; molecular evolution; monophyly; nonhuman; orthology; pla CAPN11 and µ/m-CAPN; Dykhuizen-Hartl effect; episodic gene evolution; functional constraints; functional divergence of gene family orthologues; transcriptional regulation
dc.titleA Newly Classified Vertebrate Calpain Protease, Directly Ancestral to CAPN1 and 2, Episodically Evolved a Restricted Physiological Function in Placental Mammals
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume27
dc.date.issued2010
local.identifier.absfor060407 - Genome Structure and Regulation
local.identifier.ariespublicationu9511635xPUB654
local.type.statusPublished Version
local.contributor.affiliationMacqueen, Daniel J., University of St Andrews
local.contributor.affiliationDelbridge, Margaret, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationManthri, Sujatha, University of St Andrews
local.contributor.affiliationJohnston, Ian A., University of St Andrews
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage1886
local.bibliographicCitation.lastpage1902
local.identifier.doi10.1093/molbev/msq071
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2016-02-24T12:07:28Z
local.identifier.scopusID2-s2.0-77954966042
CollectionsANU Research Publications

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