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A Newly Classified Vertebrate Calpain Protease, Directly Ancestral to CAPN1 and 2, Episodically Evolved a Restricted Physiological Function in Placental Mammals

Macqueen, Daniel J.; Delbridge, Margaret; Manthri, Sujatha; Johnston, Ian A.


The most studied members of the calpain protease superfamily are CAPN1 and 2, which are conserved across vertebrates. Another similar family member called μ/m-CAPN has been identified in birds alone. Here, we establish that μ/m-CAPN shares one-to-one or

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Molecular Biology and Evolution
DOI: 10.1093/molbev/msq071


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