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Functional STAT3 deficiency compromises the generation of human T follicular helper cells

Ma, Cindy; Avery, Danielle T; Chan, Anna; Batten, Marcel L; Bustamante, Jacinta; Boisson-Dupuis, Stephanie; Arkwright, Peter D; Kreins, Alexandra Y; Averbuch, Diana; Engelhard, Dan; Cook, Matthew; Deenick, Elissa; Tangye, Stuart


T follicular helper (Tfh) cells are critical for providing the necessary signals to induce differentiation of B cells into memory and Ab-secreting cells. Accordingly, it is important to identify the molecular requirements for Tfh cell development and function. We previously found that IL-12 mediates the differentiation of human CD4 + T cells to the Tfh lineage, because IL-12 induces naive human CD4 + T cells to acquire expression of IL-21, BCL6, ICOS, and CXCR5, which typify Tfh cells. We have...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2011-11-392985


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