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Stimulated smooth muscle neosphincter in male intrinsic sphincter deficiency: Proof of principle studies in a rabbit model

Furness, J B; Shafton, Anthony D; Hirst, George; O'Connell, Helen


Aims Intrinsic sphincter deficiency (ISD) causes significant disability and impairment of quality of life despite a range of treatment options. We investigated a novel method to improve sphincter function that does not appear to have been previously attempted, that is, transplantation to create a smooth muscle cuff, that subsequently becomes innervated, around the urethra. Methods Bladder pressure and passage of urine were measured in conscious, sedated rabbits of three groups: 6 control...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Neurourology and Urodynamics
DOI: 10.1002/nau.20835


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