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An Inflammatory Role for the Mammalian Carboxypeptidase Inhibitor Latexin: Relationship to Cystatins and the Tumour Suppressor TIG1

Aagaard, Anna; Listwan, Pawel; Cowieson, Nathan; Huber, Thomas; Ravasi, Timothy; Wells, Christine; Flanagan, Jack U; Kellie, Stuart; Hume, D A; Kobe, Bostjan; Martin, Jennifer Louise

Description

Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. Latexin is expressed in the developing brain, and we find that it plays a role in inflammation, as it is expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets. The crystal structure of mouse latexin, solved at 1.83 Å...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/61595
Source: Structure
DOI: 10.1016/j.str.2004.12.013

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