Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current
Background and purpose: Current strategies to ameliorate cardiac ischaemic and reperfusion damage, including block of the sodium-hydrogen exchanger, are therapeutically ineffective. Here we propose a different approach, block of the persistent sodium current (INaP). Experimental approach: Left ventricular pressure was measured as an index of functional deficit in isolated, Langendorff perfused, hearts from adult rats, subjected to 30 min global ischaemia and reperfusion with vehicle only...[Show more]
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|Source:||British Journal of Pharmacology|
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