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Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current

Weiss, Steven; Benoist, D; White, E; Teng, W; Saint, David Albert

Description

Background and purpose: Current strategies to ameliorate cardiac ischaemic and reperfusion damage, including block of the sodium-hydrogen exchanger, are therapeutically ineffective. Here we propose a different approach, block of the persistent sodium current (INaP). Experimental approach: Left ventricular pressure was measured as an index of functional deficit in isolated, Langendorff perfused, hearts from adult rats, subjected to 30 min global ischaemia and reperfusion with vehicle only...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/61589
Source: British Journal of Pharmacology
DOI: 10.1111/j.1476-5381.2010.00766.x

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