Life history of cones in the Rhodopsin-Mutant P23H-3 rat: Evidence of long-term survival
PURPOSE. To follow the status of cones over the life of the P23H-3 transgenic rat, while the rod population is depleted. METHODS. P23H-3 heterozygous and Sprague-Dawley (SD) control rats were raised in dim, cyclic light from postnatal day (P)10 to P540. Retinas were examined for cone density, cone outer segment (OS) length, cone axon and soma morphology, and the amplitude of rod and cone components of the electro-retinogram (ERG) were determined. RESULTS. In the P23H-3 retina, cone density...[Show more]
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|Source:||Investigative Ophthalmology and Visual Science|
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