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Mhp493 [P216] is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae

Wilton, Jody; Jenkins, Cheryl; Cordwell, Stuart J; Falconer, Linda; Minion, F; Oneal, David C; Djordjevic, Michael; Connolly, Angela; Barchia, Idris; Walker, Mark; Djordjevic, Steven P.

Description

Mycoplasma hyopneumoniae induces respiratory disease in swine by colonizing cilia causing ciliostasis, cilial loss and epithelial cell death. Heparin binds to M. hyopneumoniae cells in a dose-dependent manner and blocks its ability to adhere to porcine cilia. We show here that Mhp493 (P216), a paralogue of the cilium adhesin P97 (Mhp183), is cleaved between amino acids 1040 and 1089 generating surface-accessible, heparin-binding proteins P120 and P85. Antiphosphoserine antibodies recognized P85...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/61572
Source: Molecular Microbiology
DOI: 10.1111/j.1365-2958.2008.06546.x

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