Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Ambrus, Joseph; Halliday, Jill; Kanizaj, Nicholas; Absalom, Nathan; Harpsoe, Kaspar; Balle, Thomas; Chebib, Mary; McLeod, Malcolm

doi:10.1039/C2CC32442C

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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

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Ambrus, Joseph; Halliday, Jill; Kanizaj, Nicholas; Absalom, Nathan; Harpsoe, Kaspar; Balle, Thomas; Chebib, Mary; McLeod, Malcolm

Description

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Collections	ANU Research Publications
Date published:	2012
Type:	Journal article
URI:	http://hdl.handle.net/1885/61489
Source:	Chemical Communications
DOI:	10.1039/C2CC32442C

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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

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