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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Ambrus, Joseph; Halliday, Jill; Kanizaj, Nicholas; Absalom, Nathan; Harpsoe, Kaspar; Balle, Thomas; Chebib, Mary; McLeod, Malcolm

Description

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/61489
Source: Chemical Communications
DOI: 10.1039/C2CC32442C

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