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Approaches to the neurotrophically active natural product 11-O-debenzoyltashironin: a chemoenzymatic total synthesis of the structurally related sesquiterpene khusiol

Sharma, Mukesh; Banwell, Martin; Willis, Anthony; Rae, A David


Soothes your nerves: The enantiomerically enriched cis-1,2-dihydrocatechol 4 has been converted, over 16 steps including one involving an intramolecular Diels-Alder reaction, into the sesquiterpenoid natural product khusiol (3), which is structurally related to the neurite outgrowth-promoting natural product 11-O-debenzoyltashironin (1).

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Chemistry - An Asian Journal
DOI: 10.1002/asia.201100913


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