Kobe, Bostjan; Guncar, G; Buchholz, R; Maco, B; Cowieson, Nathan; Martin, Jennifer Louise; Marfori, Mary; Forwood, Jade; Huber, Thomas
Crystallography is commonly used for studying the structures of protein-protein complexes. However, a crystal structure does not define a unique protein-protein interface, and distinguishing a 'biological interface' from 'crystal contacts' is often not straightforward. A number of computational approaches exist for distinguishing them, but their error rate is high, emphasizing the need to obtain further data on the biological interface using complementary structural and functional approaches....[Show more]
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