Skip navigation
Skip navigation

Crystallography and protein-protein interactions: biological interfaces and crystal contacts

Kobe, Bostjan; Guncar, G; Buchholz, R; Maco, B; Cowieson, Nathan; Martin, Jennifer Louise; Marfori, Mary; Forwood, Jade; Huber, Thomas


Crystallography is commonly used for studying the structures of protein-protein complexes. However, a crystal structure does not define a unique protein-protein interface, and distinguishing a 'biological interface' from 'crystal contacts' is often not straightforward. A number of computational approaches exist for distinguishing them, but their error rate is high, emphasizing the need to obtain further data on the biological interface using complementary structural and functional approaches....[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Biochemical Society Transactions
DOI: 10.1042/BST0361438


File Description SizeFormat Image
01_Kobe_Crystallography_and_2008.pdf290.75 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator