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Use of engineered enzymes to identify organophosphate and pyrethroid-related toxicity in toxicity identification evaluations

Weston, Donald P; Jackson, Colin


Engineered variants of a carboxylesterase from Lucilia cuprina (E3) and a phosphotriesterase from Agrobacterium radiobacter (OpdA) with enhanced hydrolytic activities against pyrethroid and organophosphate pesticides were evaluated asatoxicity identification evaluation (TIE) manipulation. Reduction in toxicity in the presence of the enzyme provides an indication that the toxicant is the enzyme's target substrate. Carboxy/esterase E3 variants were evaluated to determine if the enzymes could...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Environmental Science and Technology
DOI: 10.1021/es900434z


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