Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
To efficiently catalyze a chemical reaction, enzymes are required to maintain fast rates for formation of the Michaelis complex, the chemical reaction and product release. These distinct demands could be satisfied via fluctuation between different conformational substates (CSs) with unique configurations and catalytic properties. However, there is debate as to how these rapid conformational changes, or dynamics, exactly affect catalysis. As a model system, we have studied bacterial...[Show more]
|Collections||ANU Research Publications|
|Source:||PNAS - Proceedings of the National Academy of Sciences of the United States of America|
|01_Jackson_Conformational_sampling,_2009.pdf||1.4 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.