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Identification and characterization of two families of F 420 H 2 -dependent reductases from Mycobacteria that catalyze aflatoxin degradation

Taylor, Matthew C; Jackson, Colin; Tattersall, David B; French, Nigel; Peat, T.S.; Newman, Janet; Briggs, Lyndall J; Lapalikar, Gauri V; Campbell, Peter M; Scott, Colin; Russell, Robyn J; Oakeshott , John


Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of fungal growth and contribute to serious health problems in the developing world because of their toxicity and mutagenicity. Although relatively resistant to biotic degradation, aflatoxins can be metabolized by certain species of Actinomycetales. However, the enzymatic basis for their breakdown has not been reported until now. We have identified nine Mycobacterium smegmatis enzymes that utilize the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Molecular Microbiology
DOI: 10.1111/j.1365-2958.2010.07356.x


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