Identification and characterization of two families of F 420 H 2 -dependent reductases from Mycobacteria that catalyze aflatoxin degradation
Taylor, Matthew C; Jackson, Colin; Tattersall, David B; French, Nigel; Peat, T.S.; Newman, Janet; Briggs, Lyndall J; Lapalikar, Gauri V; Campbell, Peter M; Scott, Colin; Russell, Robyn J; Oakeshott , John
Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of fungal growth and contribute to serious health problems in the developing world because of their toxicity and mutagenicity. Although relatively resistant to biotic degradation, aflatoxins can be metabolized by certain species of Actinomycetales. However, the enzymatic basis for their breakdown has not been reported until now. We have identified nine Mycobacterium smegmatis enzymes that utilize the...[Show more]
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