Pharmacokinetics of OpdA, an organophosphorus hydrolase, in the African green monkey
Organophosphorus (OP) pesticides are a broad class of acetylcholinesterase inhibitors that are responsible for tremendous morbidity and mortality worldwide, contributing to an estimated 300,000 deaths annually. Current pharmacotherapy for acute OP poisoning includes the use of atropine, an oxime, and benzodiazepines. However, even with such therapy, the mortality from these agents are as high as 40%.Enzymatic hydrolysis of OPs is an attractive new potential therapy for acute OP poisoning. A...[Show more]
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