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Kinetics and efficacy of an organophosphorus hydrolase in a rodent model of methyl-parathion poisoning

Gresham, Chip; Rosenbaum, Christopher; Gaspari, Romolo J; Jackson, Colin; Bird, Steven

Description

Objectives: Organophosphorus (OP) pesticides exert a tremendous health burden, particularly in the developing world. Limited resources, the severity of intentional OP ingestions, and a paucity of beneficial therapies all contribute to the morbidity and mortality of this broad class of chemicals. A novel theoretical treatment for OP poisoning is the use of an enzyme to degrade the parent OP in the circulation after poisoning. The aims of this study were to determine the pharmacokinetics and...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/61113
Source: Academic Emergency Medicine
DOI: 10.1111/j.1553-2712.2010.00798.x

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