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Signal Processing in the Axon Initial Segment

Kole, Maarten; Stuart, Gregory J

Description

The axon initial segment (AIS) is a specialized membrane region in the axon of neurons where action potentials are initiated. Crucial to the function of the AIS is the presence of specific voltage-gated channels clustered at high densities, giving the AIS unique electrical properties. Here we review recent data on the physiology of the AIS. These data indicate that the role of the AIS is far richer than originally thought, leading to the idea that it represents a dynamic signal processing unit...[Show more]

dc.contributor.authorKole, Maarten
dc.contributor.authorStuart, Gregory J
dc.date.accessioned2015-12-10T22:58:36Z
dc.identifier.issn0896-6273
dc.identifier.urihttp://hdl.handle.net/1885/60928
dc.description.abstractThe axon initial segment (AIS) is a specialized membrane region in the axon of neurons where action potentials are initiated. Crucial to the function of the AIS is the presence of specific voltage-gated channels clustered at high densities, giving the AIS unique electrical properties. Here we review recent data on the physiology of the AIS. These data indicate that the role of the AIS is far richer than originally thought, leading to the idea that it represents a dynamic signal processing unit within neurons, regulating the integration of synaptic inputs, intrinsic excitability, and transmitter release. Furthermore, these observations point toa critical role of the AIS in disease.
dc.publisherCell Press
dc.sourceNeuron
dc.subjectKeywords: calcium channel; potassium channel Kv1.1; potassium channel Kv1.2; sodium channel Nav1.1; sodium channel Nav1.2; sodium channel Nav1.3; sodium channel Nav1.6; action potential; axon initial segment; cell function; cell membrane; cell membrane potential; c
dc.titleSignal Processing in the Axon Initial Segment
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume73
dc.date.issued2012
local.identifier.absfor110904 - Neurology and Neuromuscular Diseases
local.identifier.ariespublicationf5625xPUB574
local.type.statusPublished Version
local.contributor.affiliationKole, Maarten, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationStuart, Gregory J, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage235
local.bibliographicCitation.lastpage247
local.identifier.doi10.1016/j.neuron.2012.01.007
dc.date.updated2016-02-24T09:27:14Z
local.identifier.scopusID2-s2.0-84856291016
local.identifier.thomsonID000299761600006
CollectionsANU Research Publications

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