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Signal Processing in the Axon Initial Segment

Kole, Maarten; Stuart, Gregory J


The axon initial segment (AIS) is a specialized membrane region in the axon of neurons where action potentials are initiated. Crucial to the function of the AIS is the presence of specific voltage-gated channels clustered at high densities, giving the AIS unique electrical properties. Here we review recent data on the physiology of the AIS. These data indicate that the role of the AIS is far richer than originally thought, leading to the idea that it represents a dynamic signal processing unit...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Neuron
DOI: 10.1016/j.neuron.2012.01.007


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