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Sex determination in mammals - before and after the evolution of SRY

Wallis, Mary; Waters, Paul; Graves, Jennifer

Description

Therian mammals (marsupials and placentals) have an XX female: XY male sex chromosome system, which is homologous to autosomes in other vertebrates. The testis-determining gene, SRY, is conserved on the Y throughout therians, but is absent in other vertebrates, suggesting that the mammal system evolved about 310 million years ago (MYA). However, recent work on the basal monotreme mammals has completely changed our conception of how and when this change occurred. Platypus and echidna lack SRY,...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/60867
Source: Cellular and Molecular Life Sciences
DOI: 10.1007/s00018-008-8109-z

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