Gene regulation induced in the C57BL/6J mouse retina by hyperoxia: a temporal microarray study
Purpose: Hyperoxia is specifically toxic to photoreceptors, and this toxicity may be important in the progress of retinal dystrophies. This study examines gene expression induced in-the C57BL/6J mouse retina by hyperoxia over the 14-day period during which photoreceptors first resist, then succumb to hyperoxia. Methods: Young adult C57BL/6J mice were exposed to hyperoxia (75% oxygen) for up to 14 days. On day 0 (control), day 3, day 7, and day 14, retinal RNA was extracted and processed on...[Show more]
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