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Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina

Natoli, Riccardo; Provis, Jan; Valter (Valter-Kocsi), Krisztina; Stone, Jonathan


PURPOSE. To examine the response of mouse retina to sustained hyperoxia. Hyperoxia is toxic to photoreceptors after sustained exposure (7-14 days in the C57BL/6J mouse) but has been reported to enhance photoreceptor function after short-term exposure. METHODS. Retinas from the hyperoxia-vulnerable C57BL/6J mouse and from the hyperoxia-resistant BALB/cJ mouse were examined after 0, 3, 7, 14, and 35 days' exposure to 75% oxygen. Quantitative PCR, TUNEL, and immunohistochemical techniques were...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.08-1722


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