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A unique H2A histone variant occupies the transcriptional start site of active genes

Soboleva, Tatiana; Nekrasov, Maxim; Pahwa, Anuj; Williams, Rohan; Huttley, Gavin Austin; Tremethick, David


Transcriptional activation is controlled by chromatin, which needs to be unfolded and remodeled to ensure access to the transcription start site (TSS). However, the mechanisms that yield such an 'open' chromatin structure, and how these processes are coordinately regulated during differentiation, are poorly understood. We identify the mouse (Mus musculus) H2A histone variant H2A.Lap1 as a previously undescribed component of the TSS of active genes expressed during specific stages of...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Nature Structural and Molecular Biology
DOI: 10.1038/nsmb.2161


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