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Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter

Ely, Fernanda; Pedroso, Marcelo M; Gahan, Lawrence; Ollis, David; Guddat, Luke; Schenk, Gerhard

Description

OpdA is a binuclear metalloenzyme that can hydrolyze organophosphate pesticides and nerve agents. In this study the crystal structure of the complex between OpdA and phosphate has been determined to 2.20 Å resolution. The structure shows the phosphate bo

dc.contributor.authorEly, Fernanda
dc.contributor.authorPedroso, Marcelo M
dc.contributor.authorGahan, Lawrence
dc.contributor.authorOllis, David
dc.contributor.authorGuddat, Luke
dc.contributor.authorSchenk, Gerhard
dc.date.accessioned2015-12-10T22:58:03Z
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/1885/60684
dc.description.abstractOpdA is a binuclear metalloenzyme that can hydrolyze organophosphate pesticides and nerve agents. In this study the crystal structure of the complex between OpdA and phosphate has been determined to 2.20 Å resolution. The structure shows the phosphate bo
dc.publisherElsevier
dc.sourceJournal of Inorganic Biochemistry
dc.subjectKeywords: Achromobacter radiobacter organophosphate degrading enzyme; bacterial enzyme; cobalt derivative; hydroxide; phosphate; unclassified drug; water; zinc derivative; article; binding kinetics; catalysis; crystal structure; enzyme structure; pH; phosphate tran Binuclear metallohydrolases; Catalytic mechanism; Organophosphate-degrading enzymes; Phosphotriesterases; X-ray crystallography
dc.titlePhosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume106
dc.date.issued2012
local.identifier.absfor039999 - Chemical Sciences not elsewhere classified
local.identifier.ariespublicationu4005981xPUB556
local.type.statusPublished Version
local.contributor.affiliationEly, Fernanda, University of Queensland
local.contributor.affiliationPedroso, Marcelo M, University of Queensland
local.contributor.affiliationGahan, Lawrence, University of Queensland
local.contributor.affiliationOllis, David, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationGuddat, Luke, University of Queensland
local.contributor.affiliationSchenk, Gerhard, University of Queensland
local.description.embargo2037-12-31
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage19
local.bibliographicCitation.lastpage22
local.identifier.doi10.1016/j.jinorgbio.2011.09.015
local.identifier.absseo960609 - Sustainability Indicators
dc.date.updated2016-02-24T10:24:44Z
local.identifier.scopusID2-s2.0-81355161239
local.identifier.thomsonID000298222600003
CollectionsANU Research Publications

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