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Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

Marshall, Heather D.; Chandele, Anmol; Jung, Yong Woo; Meng, Hailong; Poholek, Amanda C.; Parish, Ian; Rutishauser, Rachel; Cui, Weiguo; Kleinstein, Steven; Craft, Joe; Kaech, Susan

Description

CD4+ T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4+ T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8+ T cells, increased IL-7R expression was not a reliable marker of CD4+ memory precursor...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/60594
Source: Immunity
DOI: 10.1016/j.immuni.2011.08.016

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