Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53 +/- mice
Yan, Haoheng; Blackburn, Anneke; McLary, S Christine; Tao, Luwei; Roberts, Amy L.; Xavier, Elizabeth A; Dickinson, Ellen S; Seo, Jae Hong; Arenas, Richard B; Otis, Christopher; Cao, Qing; Lawlor, Rebecca G; Osborne, Barbara A; Kittrell, Frances S; Medina, Daniel; Jerry, Joseph
Mutation and loss of function in p53 are common features among human breast cancers. Here we use BALB/c-Trp53+/- mice as a model to examine the sequence of events leading to mammary tumors. Mammary gland proliferation rates were similar in both BALB/c-Trp53+/- mice and wild-type controls. In addition, sporadic mammary hyperplasias were rare in BALB/c-Trp53+/- mice and not detectably different from those of wild-type controls. Among the 28 mammary tumors collected from BALB/c-Trp53+/- mice, loss...[Show more]
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|Source:||American Journal of Pathology|
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