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Localisation of the Chromatin Remodelling Protein, ATRX in the Adult Testis

Tang, Paisu; Argentaro, Anthony; Pask, Andrew J; O'Donnell, Liza; Graves, Jennifer; Familari, Mary; Harley, Vincent R.

Description

Mutations in ATRX (alpha-thalassaemia and mental retardation on the X-chromosome) can give rise to ambiguous or female genitalia in XY males, implying a role for ATRX in testicular development. Studies on ATRX have mainly focused on its crucial role in brain development and α-globin regulation; however, little is known about its function in sexual differentiation and its expression in the adult testis. Here we show that the ATRX protein is present in adult human and rat testis and is expressed...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/60560
Source: Journal of Reproduction and Development
DOI: 10.1262/jrd.20221

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