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The ZW sex microchromosomes of an Australian dragon lizard share no homology with those of other reptiles or birds

Ezaz, Tariq; Moritz, Benjamin; Waters, Paul; Graves, Jennifer; Georges, Arthur; Sarre, Stephen

Description

Reptiles show a diverse array of sex chromosomal systems but, remarkably, the Z sex chromosomes of chicken are homologous to the ZW sex chromosomes of a species of gecko, Gekko hokouensis, suggesting an ancient but common origin. This is in contrast to the ZW sex chromosomes of snakes and a species of soft-shelled turtle, Pelodiscus sinensis, which are nonhomologous to those of chicken or each other and appear to have been independently derived. In this paper, we determine what homology, if...[Show more]

dc.contributor.authorEzaz, Tariq
dc.contributor.authorMoritz, Benjamin
dc.contributor.authorWaters, Paul
dc.contributor.authorGraves, Jennifer
dc.contributor.authorGeorges, Arthur
dc.contributor.authorSarre, Stephen
dc.date.accessioned2015-12-10T22:57:11Z
dc.identifier.issn0967-3849
dc.identifier.urihttp://hdl.handle.net/1885/60545
dc.description.abstractReptiles show a diverse array of sex chromosomal systems but, remarkably, the Z sex chromosomes of chicken are homologous to the ZW sex chromosomes of a species of gecko, Gekko hokouensis, suggesting an ancient but common origin. This is in contrast to the ZW sex chromosomes of snakes and a species of soft-shelled turtle, Pelodiscus sinensis, which are nonhomologous to those of chicken or each other and appear to have been independently derived. In this paper, we determine what homology, if any, the sex chromosomes of the Australian dragon lizard Pogona vitticeps shares with those of snake and chicken by mapping the dragon homologs of five snake Z chromosome genes (WAC, KLF6, TAX1BP1, RAB5A, and CTNNB1) and five chicken Z chromosome genes (ATP5A1, GHR, DMRT1, CHD1, and APTX) to chromosomes in the dragon. The dragon homologs of snake and chicken sex chromosome genes map to chromosomes 6 and chromosome 2, respectively, in the dragon and that DMRT1, the bird sex-determining gene, is not located on the sex chromosomes of P. vitticeps. Indeed, our data show that the dragon homolog to the chicken Z chromosome is likely to be wholly contained within chromosome 2 in P. vitticeps, which suggests that the sex-determining factor in P. vitticeps is not the sex-determining gene of chicken. Homology between chicken Z chromosome and G. hokouensis ZW chromosome pairs has been interpreted as retention of ancient ZW sex chromosomes in which case the nonhomologous sex chromosomes of snake and dragons would be independently derived. Our data add another case of independently derived sex chromosomes in a squamate reptile, which makes retention of ancient sex chromosome homology in the squamates less plausible. Alternatively, the conservation between the bird Z chromosome and the G. hokouensis ZW chromosomes pairs is coincidental, may be an example of convergent evolution, its status as the Z chromosome having been independently derived in birds and G. hokouensis.
dc.publisherKluwer Academic Publishers
dc.sourceChromosome Research
dc.subjectKeywords: animal; article; bird; chicken; genetics; lizard; reptile; sequence homology; sex chromosome; snake; Animals; Birds; Chickens; Lizards; Reptiles; Sequence Homology; Sex Chromosomes; Snakes agamidae; BAC; comparative gene mapping; dmrt1; FISH; sex determination
dc.titleThe ZW sex microchromosomes of an Australian dragon lizard share no homology with those of other reptiles or birds
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume17
dc.date.issued2009
local.identifier.absfor060403 - Developmental Genetics (incl. Sex Determination)
local.identifier.ariespublicationu9511635xPUB546
local.type.statusPublished Version
local.contributor.affiliationEzaz, Tariq, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMoritz, Benjamin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWaters, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGraves, Jennifer, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGeorges, Arthur, University of Canberra
local.contributor.affiliationSarre, Stephen, University of Canberra
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage965
local.bibliographicCitation.lastpage973
local.identifier.doi10.1007/s10577-009-9102-6
dc.date.updated2016-02-24T12:06:51Z
local.identifier.scopusID2-s2.0-77950901859
local.identifier.thomsonID000272781300002
CollectionsANU Research Publications

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