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Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts

de la Cruz, Laura; Nguyen, Thi Kelly; Ozawa, Kiyoshi; Shin, James; Graham, Bim; Otting, Gottfried; Huber, Thomas


The two-component dengue virus NS2B-NS3 protease (DEN NS2B-NS3pro) is an established drug target, but inhibitor design is hampered by the lack of a crystal structure of the protease in its fully active form. In solution and without inhibitors, the functionally important C-terminal segment of the NS2B cofactor is dissociated from DEN NS3pro ("open state"), necessitating a large structural change to produce the "closed state" thought to underpin activity. We analyzed the fold of DEN NS2B-NS3pro...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja208435s


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