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Aberrant CD8+ T-cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 signaling

D'Souza, Anthony D; Parish, Ian; McKay, Sharen E.; Kaech, Susan; Shadel, Gerald S

Description

Immune system-related pathology is common in ataxiatelangiectasia (A-T) patients and mice that lack the protein kinase, A-T mutated (ATM). However, it has not been studied how ATM influences immune responses to a viral infection. Using the lymphocytic choriomeningitis virus (LCMV) infection model, we show that ATM-/- mice, despite having fewer naïve CD8+ T cells, effectively clear the virus. However, aberrant CD8+ T-cell responses are observed, including defective expansion and contraction,...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/60453
Source: American Journal of Pathology
DOI: 10.1016/j.ajpath.2011.02.022

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