Aberrant CD8+ T-cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 signaling
Immune system-related pathology is common in ataxiatelangiectasia (A-T) patients and mice that lack the protein kinase, A-T mutated (ATM). However, it has not been studied how ATM influences immune responses to a viral infection. Using the lymphocytic choriomeningitis virus (LCMV) infection model, we show that ATM-/- mice, despite having fewer naïve CD8+ T cells, effectively clear the virus. However, aberrant CD8+ T-cell responses are observed, including defective expansion and contraction,...[Show more]
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|Source:||American Journal of Pathology|
|01_D'Souza_Aberrant_CD8+_T-cell_Responses_2011.pdf||1.99 MB||Adobe PDF||Request a copy|
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