The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer
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Murchison, Elizabeth; Tovar, Cesar; Hsu, Arthur Lian-Chi; Bender, Hannah; Kheradpour, Pouya; Rebbeck, Clare A.; Obendorf, David; Conlan, Carly; Bahlo, Melanie; Blizzard, Catherine A.; Pyecroft, Stephen; Kreiss, Alexandre; Kellis, Manolis; Stark, Alexander; Harkins, Timothy T.; Graves, Jennifer; Woods, Greg; Hannon, Gregory; Papenfuss, Anthony T
Description
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/60383 |
Source: | Science |
DOI: | 10.1126/science.1180616 |
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01_Murchison_The_Tasmanian_Devil_2010.pdf | 411.15 kB | Adobe PDF | Request a copy |
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