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The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer

Murchison, Elizabeth; Tovar, Cesar; Hsu, Arthur Lian-Chi; Bender, Hannah; Kheradpour, Pouya; Rebbeck, Clare A.; Obendorf, David; Conlan, Carly; Bahlo, Melanie; Blizzard, Catherine A.; Pyecroft, Stephen; Kreiss, Alexandre; Kellis, Manolis; Stark, Alexander; Harkins, Timothy T.; Graves, Jennifer; Woods, Greg; Hannon, Gregory; Papenfuss, Anthony T

Description

The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/60383
Source: Science
DOI: 10.1126/science.1180616

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