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Role of decay-accelerating factor in regulating survival of human cervical cancer cells

Gao, Ling-Juan; Ding, Lan; Guo, Shu-Yu; Cai, You-Qun; Su, Ya-Juan; Gong, Hui; Liu, Yun; Chen, Chen; Gu, Ping-Qing


Background: Decay-accelerating factor (DAF) is one of the key molecules involved in cell protection against autologous complement, which restricts the action of complement at critical stages of the cascade reaction. The effect of DAF on the survival of human cervical cancer cell (ME180) has not been demonstrated. Methods: In this study we applied, for the first time, small interference RNA (siRNA) to knock down the expression of the DAF with the aim of exploiting complement more effectively for...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Cancer Research and Clinical Oncology
DOI: 10.1007/s00432-010-0862-3


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