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Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis

Xue, A; Scarlett, Christopher; Chung , L; Butturini, G; Scarpa, A; Gandy, R; Wilson, Susan; Baxter, Robert; Smith, Ross C.

Description

Background and aims:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC).Methods:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and 68 healthy volunteers (HVs) were analysed by surface-enhanced laser desorption and ionisation time-of-flight mass spectrometry (SELDI-TOF MS). The resulting protein panel was validated on 40 resectable PC, 21 DC and 19 HV plasma...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/60052
Source: British Journal of Cancer
DOI: 10.1038/sj.bjc.6605764

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