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Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

Lang, Philipp A; Lang, Karl S.; Xu, Haifeng C/; Grusdat, Melanie; Parish, Ian; Recher, Mike; Elford, Alisha R.; Dhanji, Salim; Shaabani, Namir; Tran, Charles W.; Dissanayake, Dilan; Rahbar, Ramtin; Ghazarian, Magar; Brustle, Anne


Infections with HIV, hepatitis B virus, and hepatitis C virus can turn into chronic infections, which currently affect more than 500 million patients worldwide. It is generally thought that virus-mediated T-cell exhaustion limits T-cell function, thus promoting chronic disease.Here we demonstrate that natural killer (NK) cells have a negative impact on the development of T-cell immunity by using the murine lymphocytic choriomeningitis virus.NK cell-deficient (Nfil3 -/-, E4BP4 -/-)mice exhibited...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1118834109
Access Rights: Open Access


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