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Non-linear relationship between hyperpolarisation and relaxation enables long distance propagation of vasodilatation

Wolfle, Stephanie; Chaston, Daniel; Goto, Kenichi; Sandow, Shaun, L; Edwards, Frank; Hill, Caryl

Description

Blood flow is adjusted to tissue demand through rapidly ascending vasodilatations resulting from conduction of hyperpolarisation through vascular gap junctions. We investigated how these dilatations can spread without attenuation if mediated by an electrical signal. Cremaster muscle arterioles were studied in vivo by simultaneously measuring membrane potential and vessel diameter. Focal application of acetylcholine elicited hyperpolarisations which decayed passively with distance from the local...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/59874
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2010.202580

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