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Marsupial WT1 has a novel isoform and is expressed in both somatic and germ cells in the developing ovary and testis

Pask, Andrew J; Paplinska, Justyna Z; Shaw, Geoffrey; Graves, Jennifer; Renfree, Marilyn B

Description

The Wilms' tumour 1 gene is essential for the formation of the mouse and human urogenital systems. We characterised this gene and examined its expression throughout gonadal development in a marsupial, the tammar wallaby. WT1 protein was detected in the Sertoli and granulosa cells of the developing testis and ovary, respectively. There was also strong immunostaining in the germ cells of both males and females at all stages of gonadal development. In the adult gonads WT1 appears to be dynamically...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/59721
Source: Sexual Development
DOI: 10.1159/000102106

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