Reflections on the state of play in somatic hypermutation
Somatic hypermutation (SHM) of rearranged variable genes proceeds in two phases. Phase I which is well understood is triggered by activation-induced cytidine deaminase (AID) and targets mutations at C:G base pairs equally on both DNA strands. Phase II, is less well understood, and targets A:T base pairs by coopting DNA polymerase-η and acts in a strand biased fashion such that mutations off A exceed mutations of T by two- to threefold. Current molecular models attempting to explain A:T targeted...[Show more]
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