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Investigation of the potential of a 48 kDa protein as a vaccine candidate for infection against nontypable Haemophilus influenzae

Webb, Dianne; Otczyk, Diana C; Cripps, Allan


This study determined the conservation and protective efficacy of a 48 kDa nontypable Haemophilus influenzae (NTHi) protein (P48). This protein was highly conserved across the strains of NTHi examined and mucosal immunization with recombinant P48 (rP48) significantly reduced the numbers of viable NTHi recovered from the lung following challenge. rP48 induced predominantly an IgG2a antibody response that correlated with the reduction in the number of viable NTHi in the lung. These antibodies...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Vaccine
DOI: 10.1016/j.vaccine.2007.02.048


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