Total Synthesis of (±)-Vibsanin E
Vibsanin E (1), a structurally rare complex diterpene, consisting of a compact 3-oxatricyclo[6.3.2.05,10] tridecane core and an unprecedented 3,3-dimethylacroyl enol ester functional group, formulate a considerable synthetic challenge. Williams and Davies failed to independently synthesize this nemesis, however, a 'two heads are better than one' approach delivered the first total synthesis of the molecule, since its diamond aniversary isolation.
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|Source:||Australian Journal of Chemistry|
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