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Total Synthesis of (±)-Vibsanin E

Schwartz, Brett; Denton, Justin R; Davies, Huw ML; Williams, Craig

Description

Vibsanin E (1), a structurally rare complex diterpene, consisting of a compact 3-oxatricyclo[6.3.2.05,10] tridecane core and an unprecedented 3,3-dimethylacroyl enol ester functional group, formulate a considerable synthetic challenge. Williams and Davies failed to independently synthesize this nemesis, however, a 'two heads are better than one' approach delivered the first total synthesis of the molecule, since its diamond aniversary isolation.

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/59576
Source: Australian Journal of Chemistry
DOI: 10.1071/CH09267

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