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Rapid evolution of a novel signalling mechanism by concerted duplication and divergence of a BMP ligand and its extracellular modulators

Fritsch, Cornelia; Lanfear, Robert; Ray, Robert P.


Gene duplication and divergence is widely considered to be a fundamental mechanism for generating evolutionary novelties. The Bone Morphogenetic Proteins (BMPs) are a diverse family of signalling molecules found in all metazoan genomes that have evolved by duplication and divergence from a small number of ancestral types. In the fruit fly Drosophila, there are three BMPs: Decapentaplegic (Dpp) and Glass bottom boat (Gbb), which are the orthologues of vertebrate BMP2/4 and BMP5/6/7/8,...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Development Genes and Evolution
DOI: 10.1007/s00427-010-0341-5


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