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The Global Spread of Hepatitis C Virus 1a and 1b: A Phylodynamic and Phylogeographic Analysis

Magiorkinis, Gkikas; Magiorkinis, Emmanouil; Paraskevis, Dimitrios; Ho, Simon; Shapiro, Beth; Pybus, Oliver G; Allain, Jean-Pierre; Hatzakis, Angelos


Background: Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa. Previous attempts to estimate the spatiotemporal parameters of the virus, both globally and regionally, have suggested that epidemic HCV transmission began in 1900 and grew steadily until the late 1980s. However, epidemiological data suggest that the expansion of HCV may have...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: PLoS Medicine
DOI: 10.1371/journal.pmed.1000198


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