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Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

Cao, Feihua (Lucy); Gamble, Allan; Kim, Hye-Kyung; Onagi, Hideki; Gresser, Mary; Kerr, Jamie; Easton, Christopher

Description

Fatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine deriva

dc.contributor.authorCao, Feihua (Lucy)
dc.contributor.authorGamble, Allan
dc.contributor.authorKim, Hye-Kyung
dc.contributor.authorOnagi, Hideki
dc.contributor.authorGresser, Mary
dc.contributor.authorKerr, Jamie
dc.contributor.authorEaston, Christopher
dc.date.accessioned2015-12-10T22:53:23Z
dc.identifier.issn2040-2503
dc.identifier.urihttp://hdl.handle.net/1885/59329
dc.description.abstractFatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine deriva
dc.publisherRoyal Society of Chemistry
dc.sourceMedChemComm
dc.subjectKeywords: alpha amidating enzyme; alpha amidating enzyme inhibitor; glycine derivative; oxygenase inhibitor; procalcitonin; thioester; unclassified drug; article; binding affinity; cancer cell culture; controlled study; drug potency; drug selectivity; enzyme inhibi
dc.titlePotent and selective inhibitors of human peptidylglycine α-amidating monooxygenase
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume2
dc.date.issued2011
local.identifier.absfor030406 - Proteins and Peptides
local.identifier.ariespublicationu4005981xPUB485
local.type.statusPublished Version
local.contributor.affiliationCao, Feihua (Lucy), College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationGamble, Allan, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKim, Hye-Kyung, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOnagi, Hideki, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationGresser, Mary, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKerr, Jamie, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationEaston, Christopher, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage760
local.bibliographicCitation.lastpage763
local.identifier.doi10.1039/c1md00079a
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
dc.date.updated2016-02-24T10:24:26Z
local.identifier.scopusID2-s2.0-79961158916
local.identifier.thomsonID000295068100011
CollectionsANU Research Publications

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