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PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis

Hetherington, Suzannah; Gally, Christelle; Fritz, Julie-Anne; Polanowska, Jolanta; Reboul, Jerome; Schwab, Yannick; Zahreddine, Hala; Behm, Carolyn; Labouesse, Michel


Caenorhabditis elegans embryonic elongation depends on both epidermal and muscle cells. The hemidesmosome-like junctions, commonly called fibrous organelles (FOs), that attach the epidermis to the extracellular matrix ensure muscle anchoring to the cuticular exoskeleton and play an essential role during elongation. To further define how hemidesmosomes might control elongation, we searched for factors interacting with the core hemidesmosome component, the spectraplakin homolog VAB-10. Using the...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Developmental Biology
DOI: 10.1016/j.ydbio.2010.11.025


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