Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy
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Swarbrick, James; Ung, Phuc; Su, Xun-Cheng; Maleckis, Ansis; Chhabra, Sandeep; Graham, Bim; Otting, Gottfried; Huber, Thomas
Description
Attachment of two nitrilotriacetic acid-based ligands to a protein α-helix in an i, i + 4 configuration produces an octadentate chelating motif that is able to bind paramagnetic lanthanide ions rigidly and with high affinity, leading to large pseudoconta
dc.contributor.author | Swarbrick, James | |
---|---|---|
dc.contributor.author | Ung, Phuc | |
dc.contributor.author | Su, Xun-Cheng | |
dc.contributor.author | Maleckis, Ansis | |
dc.contributor.author | Chhabra, Sandeep | |
dc.contributor.author | Graham, Bim | |
dc.contributor.author | Otting, Gottfried | |
dc.contributor.author | Huber, Thomas | |
dc.date.accessioned | 2015-12-10T22:51:19Z | |
dc.identifier.issn | 1359-7345 | |
dc.identifier.uri | http://hdl.handle.net/1885/58994 | |
dc.description.abstract | Attachment of two nitrilotriacetic acid-based ligands to a protein α-helix in an i, i + 4 configuration produces an octadentate chelating motif that is able to bind paramagnetic lanthanide ions rigidly and with high affinity, leading to large pseudoconta | |
dc.publisher | Royal Society of Chemistry | |
dc.source | Chemical Communications | |
dc.subject | Keywords: edetic acid; lanthanide; nitrilotriacetic acid; alpha helix; article; binding affinity; cross coupling reaction; ligand binding; nuclear magnetic resonance spectroscopy; protein binding; protein engineering; protein motif; protein protein interaction; Ami | |
dc.title | Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 47 | |
dc.date.issued | 2011 | |
local.identifier.absfor | 060112 - Structural Biology (incl. Macromolecular Modelling) | |
local.identifier.absfor | 030503 - Organic Chemical Synthesis | |
local.identifier.absfor | 030606 - Structural Chemistry and Spectroscopy | |
local.identifier.ariespublication | u4005981xPUB468 | |
local.type.status | Published Version | |
local.contributor.affiliation | Swarbrick, James, Monash University | |
local.contributor.affiliation | Ung, Phuc, Monash Institute of Pharmaceutical Sciences | |
local.contributor.affiliation | Su, Xun-Cheng, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Maleckis, Ansis, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Chhabra, Sandeep, Monash Institute of Pharmaceutical Sciences | |
local.contributor.affiliation | Huber, Thomas, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Otting, Gottfried, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Graham, Bim, Monash University | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 26 | |
local.bibliographicCitation.startpage | 7368 | |
local.bibliographicCitation.lastpage | 7370 | |
local.identifier.doi | 10.1039/c1cc11893e | |
local.identifier.absseo | 860803 - Human Pharmaceutical Treatments (e.g. Antibiotics) | |
dc.date.updated | 2016-02-24T10:24:17Z | |
local.identifier.scopusID | 2-s2.0-79959383052 | |
local.identifier.thomsonID | 000291823400020 | |
Collections | ANU Research Publications |
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