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Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy

Swarbrick, James; Ung, Phuc; Su, Xun-Cheng; Maleckis, Ansis; Chhabra, Sandeep; Huber, Thomas; Otting, Gottfried; Graham, Bim


Attachment of two nitrilotriacetic acid-based ligands to a protein α-helix in an i, i + 4 configuration produces an octadentate chelating motif that is able to bind paramagnetic lanthanide ions rigidly and with high affinity, leading to large pseudoconta

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Chemical Communications
DOI: 10.1039/c1cc11893e


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