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Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy

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Swarbrick, James; Ung, Phuc; Su, Xun-Cheng; Maleckis, Ansis; Chhabra, Sandeep; Graham, Bim; Otting, Gottfried; Huber, Thomas

Description

Attachment of two nitrilotriacetic acid-based ligands to a protein α-helix in an i, i + 4 configuration produces an octadentate chelating motif that is able to bind paramagnetic lanthanide ions rigidly and with high affinity, leading to large pseudoconta

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/58994
Source: Chemical Communications
DOI: 10.1039/c1cc11893e

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