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Mining electron density for functionally relevant protein polysterism in crystal structures

Fraser, James S; Jackson, Colin


This review focuses on conceptual and methodological advances in our understanding and characterization of the conformational heterogeneity of proteins. Focusing on X-ray crystallography, we describe how polysterism, the interconversion of pre-existing conformational substates, has traditionally been analyzed by comparing independent crystal structures or multiple chains within a single crystal asymmetric unit. In contrast, recent studies have focused on mining electron density maps to reveal...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Cellular and Molecular Life Sciences
DOI: 10.1007/s00018-010-0611-4


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