Mining electron density for functionally relevant protein polysterism in crystal structures
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Fraser, James S; Jackson, Colin
Description
This review focuses on conceptual and methodological advances in our understanding and characterization of the conformational heterogeneity of proteins. Focusing on X-ray crystallography, we describe how polysterism, the interconversion of pre-existing conformational substates, has traditionally been analyzed by comparing independent crystal structures or multiple chains within a single crystal asymmetric unit. In contrast, recent studies have focused on mining electron density maps to reveal...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/58974 |
Source: | Cellular and Molecular Life Sciences |
DOI: | 10.1007/s00018-010-0611-4 |
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File | Description | Size | Format | Image |
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01_Fraser_Mining_electron_density_for_2011.pdf | 466.64 kB | Adobe PDF | Request a copy |
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