Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA)
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Ely, Fernanda; Hadler, Kieran S; Mitic, Natasa; Gahan, Lawrence; Ollis, David; Plugis, Nicholas M.; Russo, Marie T; Larrabee, James A; Schenk, Gerhard
Description
The organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA) is a highly efficient catalyst for the degradation of pesticides and some nerve agents such as sarin. OpdA requires two metal ions for catalytic activity, and hydrolysis is initiated by a nucleophilic hydroxide that is bound to one of these metal ions. The precise location of this nucleophile has been contentious, with both a terminal and a metal-ion-bridging hydroxide as likely candidates. Here, we employed magnetic...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/58844 |
Source: | Journal of Biological Inorganic Chemistry |
DOI: | 10.1007/s00775-011-0779-6 |
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01_Ely_Electronic_and_geometric_2011.pdf | 881.99 kB | Adobe PDF | Request a copy |
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