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Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA)

Ely, Fernanda; Hadler, Kieran S; Mitic, Natasa; Gahan, Lawrence; Ollis, David; Plugis, Nicholas M.; Russo, Marie T; Larrabee, James A; Schenk, Gerhard


The organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA) is a highly efficient catalyst for the degradation of pesticides and some nerve agents such as sarin. OpdA requires two metal ions for catalytic activity, and hydrolysis is initiated by a nucleophilic hydroxide that is bound to one of these metal ions. The precise location of this nucleophile has been contentious, with both a terminal and a metal-ion-bridging hydroxide as likely candidates. Here, we employed magnetic...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Biological Inorganic Chemistry
DOI: 10.1007/s00775-011-0779-6


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