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Logic and extent of miRNA-mediated control of autoimmune gene expression

Garcia De Vinuesa, Maria Carola; Rigby, Robert; Yu, Di


Over the past few decades, multiple mechanisms have emerged that operate to prune the lymphocyte repertoire of self-reactive specificities and maintain immunological tolerance. Multiple families of small noncoding RNAs known as microRNAs (miRNAs) target immune transcripts to fine-tune gene expression and turn on negative feedback loops. Both of these actions are crucial to limit co-stimulation, set precise cellular activation thresholds, curtail inflammation, control lymphocyte growth, and...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: International Reviews of Immunology
DOI: 10.1080/08830180902934909


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