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DMRT gene cluster analysis in the platypus: New insights into genomic organization and regulatory regions

El-Mogharbel, Nisrine; Wakefield, Matthew; Deakin, Janine; Tsend-Ayush, Enkhjargal; Gruetzner, Frank; Alsop, Amber; Ezaz, Tariq; Graves, Jennifer


We isolated and characterized a cluster of platypus DMRT genes and compared their arrangement, location, and sequence across vertebrates. The DMRT gene cluster on human 9p24.3 harbors, in order, DMRT1, DMRT3, and DMRT2, which share a DM domain. DMRT1 is highly conserved and involved in sexual development in vertebrates, and deletions in this region cause sex reversal in humans. Sequence comparisons of DMRT genes between species have been valuable in identifying exons, control regions, and...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Genomics
DOI: 10.1016/j.ygeno.2006.07.017


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