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Membrane potential bistability is controlled by the hyperpolarization-activated current IH in rat cerebellar Purkinje neurons in vitro

Williams, Stephen; Christensen, Soren; Stuart, Gregory J; Hausser, Michael


We investigated the role of the hyperpolarization-activated mixed cation current, IH, in the control of spontaneous action potential firing of rat cerebellar Purkinje neurons in brain slices. Extracellular recordings revealed that the continual action potential firing of Purkinje neurons was disrupted by the pharmacological blockade of IH. Blockade of IH revealed spontaneous transitions between periods of tonic action potential firing and quiescence, without effects on the frequency or variance...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2001.013136


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